pH analytical applications in the life sciences industry
Increase the quality of your measurements and final product
Media preparation analytics
Measuring consistency from process to lab, is key
For optimum production yield, each pH sensor needs to be carefully adjusted. Media and buffer solutions used in bioprocesses need to be carefully controlled, as they have direct influence on the yield. Process values are commonly controlled in the laboratory. The following factors must be considered:
- Discrepancies in measurement values between laboratory and process measurements must be avoided
- Sensors are carefully evaluated and identical sensors are used in process and in the lab
Fermentation and cell cultivation
It is vital to create the right conditions in the bioreactor to allow microorganisms or cells to thrive. This ensures that yields are maximized in a stable and predictable manner. pH measurement is done in order to compensate for changes during the running process. The electrode’s measuring stability is critical during this process, as well as after the CIP and the SIP.
During the fermentation process, industries must avoid any sensor exchange due to risk of contamination. After the sensor has been installed and cleaned (SIP), it must provide a reliable measurement value through the batch. Drifting measurement values after SIP and during the batch must be minimized. Only SIP-stable high end sensors can be used. SOP (standard operation procedures) specify an exact workflow that also includes sensor handling. Sensor handling must be easy and uniform.
Purification and chromatography
Chromatography is a process wherein a mixture of different bioengineered products and proteins are separated and purified based on their different dwell times between stationary and mobile phases. At this stage, pH is measured to optimize the separation condition. With the use of Memosens digital sensors in chromatography, reliability of measurement improves thanks to a stable signal after autoclavation.